2-Iodophenol (o-iodophenol) is an aromatic organic compound with the formula IC6H4OH. It is a pale yellow solid that melts near room temperature. It undergoes a variety of coupling reactions in which the iodine substituent is replaced by a new carbon group ortho to the hydroxy group of the phenol, which can be followed by cyclization to form heterocycles. It can be prepared by treatment of 2-chloromercuriphenol with iodine:
ClHgC6H4OH + I2 → IC6H4OH + HgCl(I) Direct reaction of phenol with iodine gives a mixture of 2- and 4-iodo derivatives.
References
Cited sources Haynes, William M., ed. (2016). CRC Handbook of Chemistry and Physics (97th ed.). CRC Press. ISBN 9781498754293.