7α-Methylestradiol (7α-Me-E2), also known as 7α-methylestra-1,3,5(10)-triene-3,17β-diol, is a synthetic estrogen and an active metabolite of the androgen/anabolic steroid Trestolone. It is considered to be responsible for the estrogenic activity of trestolone. The compound shows about higher affinity for the androgen receptor than estradiol.
Synthesis The chemical synthesis of the 17-acetate ester starting from trestolone acetate has been described (but this is old work). Alternative procedures exist, e.g. 7α-Methylestradiol can be used to prepare 7 alpha-methyl-19-nor-androstatrienes such as for example a compound that is called 3-oxo-7a-methyl-17b-acetoxy-17a-ethynyl-4-9,11-19-norandrostatriene.
See also List of estrogens Methylestradiol Ethylestradiol Ethinylestradiol Almestrone
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