The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role in ketone body utilization and fatty acid synthesis. The gene is found on human chromosome 12. The AACS protein is a member of the acyl-CoA synthetase family and is involved in cellular energy production, ketogenesis, and cholesterol synthesis. It is expressed in a wide range of human tissues.
Function The protein's function is regulated transcriptionally by sterol regulatory element-binding protein (SREBP) and peroxisome proliferator-activated receptor gamma (PPARγ).
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