Amelogenin, Y isoform is a protein that in humans is encoded by the AMELY gene. AMELY is located on the Y chromosome and encodes a form of amelogenin. Amelogenin is an extracellular matrix protein involved in biomineralization during tooth enamel development.
Clinical significance Mutations in the related AMELX gene on the X chromosome cause X-linked amelogenesis imperfecta. The presence or lack of the Y isoform of Amelogenin in fossilized enamel can be used to determine the sex of ancient hominids.
References
External links Human AMELY genome location and AMELY gene details page in the UCSC Genome Browser.
Further reading