Acclimatisation is the process by which the nervous system fails to respond to a stimulus, as a result of the repeated stimulation of a transmission across a synapse. Acclimatisation is believed to occur when the synaptic knob of the presynaptic neuron runs out of vesicles containing neurotransmitters due to overuse over a short period of time. A synapse that has undergone acclimatisation is said to be fatigued. Acclimatisation is said to be responsible for 'getting used to' background noises and smells.
See also Adaptive system Neural adaptation
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