Adenosquamous carcinoma is a type of cancer that contains two types of cells: squamous cells (thin, flat cells that line certain organs) and gland-like cells. It has been associated with more aggressive characteristics when compared to adenocarcinoma in certain cancers. It is responsible for 1% to 4% of exocrine forms of pancreas cancer.
Diagnosis
Light microscopy shows a combination of gland-like cells and squamous epithelial cells. On immunohistochemistry, it is typically positive for CK5/6, CK7 and p63, and negative for CK20, p16 and p53. On genetic testing, KRAS and p53 are typically altered.
References
External links
Adenosquamous carcinoma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.