B-777-81 is an antidepressant drug candidate. B777-81 works by reversing reserpine and tetrabenazine-induced ptosis in a similar manner to that of imipramine, but with a shorter duration of action. It also antagonizes reserpine-induced hypothermia but it is without effect on the decrease in locomotor activity or catalepsy following reserpine. In vitro, B777-81 inhibited 5-HT uptake in platelets, potentiated the effect of NA on isolated vas deferens and had less anticholinergic effect than imipramine in the isolated ileum.
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