Buspirone/zolmitriptan, also known by its developmental code names AV-2860 and JM-010, is a combination of buspirone, a serotonin 5-HT1A receptor partial agonist, and zolmitriptan, a serotonin 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptor agonist, which is under development for the treatment of drug-induced dyskinesia, specifically levodopa-induced dyskinesia in people with Parkinson's disease. It is taken orally. The drug is under development by Contera Pharma and Bukwang Pharmaceutical. As of November 2024, it is in phase 2 clinical trials for treatment of drug-induced dyskinesia. Buspirone/zolmitriptan has failed to meet its endpoints in phase 2 trials.
See also List of investigational Parkinson's disease drugs Befiradol (F-13640; NLX-112) Piclozotan (SUN-4057)
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