CTW0404 is an experimental drug which is described as a positive allosteric modulator of the 5-HT2A receptor, with neutral or negative modulation of the related 5-HT2B and 5-HT2C subtypes. It does not produce the head-twitch response in animal studies, and reduces the head-twitch response produced by DOI, suggesting that it may be a biased allosteric modulator selective for certain signalling pathways.
See also 5-HT2A receptor § Positive allosteric modulators CTW0415 AB0124
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