Centrilobular necrosis (CN) is a nonspecific histopathological observation brought on by hepatotoxins like acetaminophen (paracetamol), thioacetamide, tetrachloride, cardiac hepatopathy due to acute right sided cardiac failure, and congestive hepatic injury in veno-occlusive disease, or hypoxic injury due to ischemia. Centrilobular necrosis can also be found in those with autoimmune hepatitis. Centrilobular necrosis is characterized by necrotic hepatocytes completely encircling the central vein.
Outlook After a single or brief exposure to a toxicant, hepatocytes that have suffered centrilobular necrosis typically heal quickly; the liver can regain its normal appearance under a microscope in about a week. Nevertheless, fibrosis, which may be slight, occurs in the previously necrotic zone surrounding the central vein when regeneration replaces the necrotic hepatocytes if sinusoidal cells and the normal scaffolding are destroyed.
See also Hepatotoxicity Ischemic hepatitis
References
Further reading Krishna, Murli (2017). "Patterns of necrosis in liver disease". Clinical Liver Disease. 10 (2). Ovid Technologies (Wolters Kluwer Health): 53–56. doi:10.1002/cld.653. ISSN 2046-2484. PMC 6467231. PMID 30992760. Misdraji, Joseph; Thiim, Michael; Graeme-Cook, Fiona M (2004). "Autoimmune Hepatitis With Centrilobular Necrosis". The American Journal of Surgical Pathology. 28 (4). Ovid Technologies (Wolters Kluwer Health): 471–478. doi:10.1097/00000478-200404000-00006. ISSN 0147-5185. S2CID 20808570.
External links WebPath Forms of hepatic injury at Pathology Outlines.