Chondroitin ABC lyase (EC 4.2.2.20 EC 4.2.2.21, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic name chondroitin ABC lyase. This enzyme catalyses the following chemical reaction
Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate.
Uses
Following a spinal cord injury, this enzyme can be used to erode scar tissue that can interfere with regeneration.
References
External links Chondroitin+ABC+lyase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)