The core binding factor (CBF) is a group of heterodimeric transcription factors. Core binding factors are composed of:
a non-DNA-binding CBFβ chain (InterPro: IPR003417) Human: CBFB a DNA-binding CBFα chain (InterPro: IPR016554) Human: RUNX1, RUNX2, RUNX3
References de Bruijn M, Speck N (2004). "Core-binding factors in hematopoiesis and immune function". Oncogene. 23 (24): 4238–48. doi:10.1038/sj.onc.1207763. PMID 15156179.
See also AI-10-49, an anti-leukemic drug under development.
External links Core+Binding+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)