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Craig plot

Craig plot

The Craig plot, named after Paul N. Craig, is a plot of two substituent parameters (e.g. Hansch-Fujita π constant and sigma constant) used in rational drug design. Two most used forms of a Craig plot are

plotting the sigma constants of the Hammett equation versus hydrophobicity plotting the steric terms of the Taft equation against hydrophobicity

See also Quantitative structure-activity relationship pKa

References

Further reading Craig, Paul N. (1971). "Interdependence between physical parameters and selection of substituent groups for correlation studies". Journal of Medicinal Chemistry. 14 (8): 680–684. doi:10.1021/jm00290a004. PMID 5114063.

Tags

  • Medicinal chemistry
  • Medicinal chemistry stubs