Dihydrouracil is an intermediate in the catabolism of uracil. The enzyme dihydrouracil dehydrogenase (NAD+) converts uracil to dihydrouracil:
The enzyme uses reduced nicotinamide adenine dinucleotide (NADH) as its cofactor. Dihydrouracil is the base present in the nucleoside dihydrouridine.
See also Dihydrouracil oxidase Dihydropyrimidinase
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