Dimethylcurcumin (development code ASC-J9) is a nonsteroidal antiandrogen and a synthetic curcuminoid. In vitro, it is an androgen receptor (AR) inhibitor and shows antiandrogenic activity, although its mechanism of action and effects differ from those of conventional antiandrogens; it is not an antagonist of the AR and instead appears to act as a selective degradation enhancer of certain subpopulations of the AR, for instance those present in the prostate gland.
See also List of investigational sex-hormonal agents § Androgenics Rosolutamide (ASC-JM17, JM17, ALZ-003)
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