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DopAmide

DopAmide

DopAmide, or L-DopAmide, is a synthetic levodopa (L-DOPA) analogue that can serve as a levodopa and dopamine prodrug and is of potential interest in the treatment of Parkinson's disease. DopAmide has an amide rather than the carboxyl group of L-DOPA, which imparts greater water solubility. The amide is hydrolyzed back to the acid by aminopeptidase enzymes.

See also DA-Phen Foslevodopa Melevodopa Etilevodopa O,O′-Diacetyldopamine O,O′-Dipivaloyldopamine Neurotransmitter prodrug

References

Tags

  • Amides
  • Antiparkinsonian agents
  • Catecholamines
  • Dopamine agonists
  • Experimental drugs
  • Monoamine precursors
  • Nervous system drug stubs
  • Prodrugs