Efrapeptins are peptides produced by fungi in the genus Tolypocladium that have antifungal, insecticidal, and mitochondrial ATPase inhibitory activities. They are produced via a biosynthetic pathway similar to, but simpler than, the ciclosporin pathway with nonribosomal peptide synthase (NRPS) and/or polyketide synthase (PKS) being the key elements. The amino acid sequences of efrapeptins are:
Efrapeptin F: Ac-Pip-Aib-Pip-Aib-Aib-Leu-bAla-Gly-Aib-Aib-Pip-Aib-Ala-Leu-Iva-Unk Efrapeptin G: Ac-Pip-Aib-Pip-Iva-Aib-Leu-bAla-Gly-Aib-Aib-Pip-Aib-Ala-Leu-Iva-Unk Aib: 2-methylalanine; Iva: 2-ethylalanine; Unk: does not match to a known amino acid
References
External links
CID 3081780 from PubChem - Efrapeptin F Efrapeptin F at ChemSpider CID 44566255 from PubChem - Efrapeptin G Efrapeptin G at ChemSpider