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Fosaprepitant

Fosaprepitant

Fosaprepitant, sold under the brand names Emend (US) and Ivemend (EU) among others, is an antiemetic medication, administered intravenously. Fosaprepitant is a substance P/neurokinin-1 (NK1) receptor antagonist. It is a prodrug of aprepitant. Fosaprepitant was developed by Merck & Co. and was approved for medical use in the United States, and in the European Union in January 2008.

Medical uses Fosaprepitant is indicated for people aged six months of age and older, in combination with other antiemetic agents, for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy including high-dose cisplatin; and for delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy.

References

External links Fosaprepitant ( Code - C72787 ) at National Cancer Institute Fosaprepitant Dimeglumine ( Code - C72788 ) at National Cancer Institute

Tags

  • 3,5-bis(Trifluoromethyl)phenyl compounds
  • 4-Fluorophenyl compounds
  • Antiemetics
  • CYP3A4 inhibitors
  • Drugs developed by Merck & Co.
  • Ethers
  • Gastrointestinal system drug stubs
  • Morpholines
  • NK1 receptor antagonists
  • Nervous system drug stubs
  • Phosphoramidates
  • Prodrugs