astronomy

Fumio Takei

Fumio Takei is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Fumio Takei rather than just read about it. In short: Fumio Takei is a Distinguished Scientist at the Provincial Health Services Authority and Terry Fox Laboratory, part of the British Columbia Cancer Agency. in Vancouver. He also is a Professor of Pathology and Laboratory Medicine at the University of British Columbia, Canada.

Key takeaways

Fumio Takei belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Fumio Takei to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Fumio Takei from memory before moving on to harder problems.

Reference excerpt

Fumio Takei is a Distinguished Scientist at the Provincial Health Services Authority and Terry Fox Laboratory, part of the British Columbia Cancer Agency. in Vancouver. He also is a Professor of Pathology and Laboratory Medicine at the University of British Columbia, Canada.

Education In 1968, he received his bachelor's degree in biochemistry from the University of Tokyo, Japan. He continued his studies in immunology under the supervision of Dr. Julia Levy at the University of British Columbia(UBC) where he received his Ph.D. in 1976. His thesis was focused on “Specific Suppressor Cells in Mice Bearing a Syngeneic Mastocytoma” Takei held a postdoctoral position in Microbiology at the University of British Columbia. He also trained at the MRC Laboratory of Molecular Biology, Cambridge, England as a postdoctoral fellow with Drs. César Milstein and Ed Lennox before starting his own laboratory at the University of British Columbia.

Research and career Takei has more than 30 years of experience in immunology, particularly innate lymphocytes. From 1990 to 2010, he mainly focused on the development and regulation of natural killer (NK) cell functions. In the beginning, he was more interested in T cells than NK cells. When his lab first cloned Ly-49, they found that it is a member of a large genetically related family rather than a T-cell receptor(TCR). This happened before the first T cell receptor was cloned. Continuing this project was challenging at that time since the sequence of Ly-49 was not indicative of its function. However, after Wayne Yokoyama found that Ly-49 is MHC-I specific receptor on NK cells, Dr. Takei's lab continued working on other members of this family. They showed that each member of this family of highly polymorphic NK receptors, has distinct specificity for MHC I. This is one of the biggest contributions to NK cell studies. In 2010, while his lab was working on NK cells, they found an interesting similarity between natural helper (NH) cells and NK cells progenitors. They isolated natural helper (NH)-like cells from allergen-treated mouse lung and found the production of cytokines type 2, IL-5, and IL-13 in these population. Identifying T cell-independent type 2 inflammation using an in vivo model of papain-induced lung resulted in finding a unique group of lymphocytes in mouse lungs, currently known as group 2 innate lymphoid cell (ILC2s). They showed that the production of Th-2 type cytokines in these populations involved in allergic inflammation. Moreover, they proved that ILC2s play a major role in allergen-induced lung inflammation by developing ILC2 deficient mice. More studies by his group showed other roles of ILC2s such as acquiring memory functions. His lab is currently studying the regulation of ILC2s and their functional and developmental relationship with other lymphocytes as well as identifying other ILC populations induced by different allergens like ILC3s. They are also working on differences between tissue-resident versus migratory ILC2s.

Memberships Society for Mucosal Immunology: Milwaukee, Wisconsin, US Canadian Society of Immunology: Winnipeg, MB, CA American Association of Immunologists: Rockville, Maryland, US

Selected publications Ghaedi, M., Shen, Z., Orangi, M., Martinez-Gonzalez, I., Wei, L., Lu, X., Das, A., Heravi-Moussavi, A., Marra, M., Bhandoola, A. and Takei, F., 2019. Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets. Journal of Experimental Medicine, 217(3). Halim T, MacLaren A, Romanish M, Gold M, McNagny K, Takei F. Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation. Immunity. 2012;37(3):463-474. doi:10.1016/j.immuni.2012.06.012 Akira Kubota, Satoko Kubota, Stefan Lohwasser, Dixie L. Mager, Fumio Takei. Diversity of NK Cell Receptor Repertoire in Adult and Neonatal Mice. The Journal of Immunology July 1, 1999, 163 (1) 212–216; Horley, K., Carpenito, C., Baker, B. and Takei, F., 1989. Molecular cloning of murine intercellular adhesion molecule (ICAM-1). The EMBO Journal, 8(10), pp. 2889–2896. Takei, F., Waldmann, H., Lennox, E. and Milstein, C., 1980. Monoclonal antibody H 9/25 reacts with functional subsets of T and B cells: killer, killer precursor and plaque-forming cells. European Journal of Immunology, 10(7), pp. 503–509. Takei, F., Galfré, G., Alderson, T., Lennox, E. and Milstein, C., 1980. H9/25 monoclonal antibody recognizes a new allospecificity of mouse lymphocyte subpopulations: Strain and tissue distribution. European Journal of Immunology, 10(4), pp. 241–246.

References

Worked examples

Example 1 — a first encounter with Fumio Takei

Start with the simplest possible case. Write down what Fumio Takei claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Fumio Takei before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Fumio Takei ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Fumio Takei

In research: Fumio Takei appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Fumio Takei in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Fumio Takei is common in secondary-school and first-year university syllabi. It links to neighbouring topics Academic staff of the University of British Columbia, Canadian medical researchers, Immunologists, so understanding it makes those chapters shorter.
In everyday life: Look for Fumio Takei outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Fumio Takei in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Fumio Takei means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Fumio Takei out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Fumio Takei in simple terms?

Why does Fumio Takei matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Fumio Takei?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Fumio Takei.