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GPR146

GPR146 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand GPR146 rather than just read about it. In short: G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. The receptor has been shown to bind cholesin, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption.

GPR146 — main illustration
GPR146 — illustration

Key takeaways

  • GPR146 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect GPR146 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of GPR146 from memory before moving on to harder problems.

Reference excerpt

G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. The receptor has been shown to bind cholesin, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions. GPR146 has also been identified as a possible receptor for C-peptide.

References

Further reading

Illustrations

GPR146 illustration
GPR146 illustration
GPR146 illustration
GPR146 illustration

Worked examples

Example 1 — a first encounter with GPR146

Start with the simplest possible case. Write down what GPR146 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to GPR146 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about GPR146 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of GPR146

In research
GPR146 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses GPR146 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
GPR146 is common in secondary-school and first-year university syllabi. It links to neighbouring topics G protein-coupled receptors, Genes on human chromosome 7, Transmembrane receptor stubs, so understanding it makes those chapters shorter.
In everyday life
Look for GPR146 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study GPR146 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what GPR146 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain GPR146 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is GPR146 in simple terms?

G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. The receptor has been shown to bind cholesin, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption.

Why does GPR146 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study GPR146?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on GPR146.

Tags

  • G protein-coupled receptors
  • Genes on human chromosome 7
  • Transmembrane receptor stubs

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