G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.
Function GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate. GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.
Ligand
Inverse Agonist Cannabidiol Solangepras (solengepras; CVN-424)
Evolution
Paralogues to GPR6 gene Source:
GPR3 GPR12 S1PR5 S1PR1 CNR1 S1PR2 LPAR2 CNR2 MC1R S1PR3 S1PR4 GPR119 MC3R MC4R MC5R LPAR1 LPAR3 MC2R
See also Lysophospholipid receptor
References
Further reading
External links "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-02. Retrieved 2009-04-24.






