science

GT-2203

GT-2203 is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand GT-2203 rather than just read about it. In short: GT-2203, also known as VUF-5296, (1R,2R)-cyclopropylhistamine, or (1R,2R)-trans-2-(1H-imidazol-4-yl)cyclopropylamine, is a histamine H3 receptor agonist which was under development for the treatment of insomnia and anxiety disorders but was never marketed. Its route of administration was unspecified.

Key takeaways

GT-2203 belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect GT-2203 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of GT-2203 from memory before moving on to harder problems.

Reference excerpt

GT-2203, also known as VUF-5296, (1R,2R)-cyclopropylhistamine, or (1R,2R)-trans-2-(1H-imidazol-4-yl)cyclopropylamine, is a histamine H3 receptor agonist which was under development for the treatment of insomnia and anxiety disorders but was never marketed. Its route of administration was unspecified.

Pharmacology The drug is a synthetic derivative of the neurotransmitter histamine. The other enantiomer, (1S,2S)-cyclopropylhistamine (VUF-5297), is about 10-fold more potent than GT-2203 as a histamine H3 receptor agonist. Both enantiomers are partial agonists of the receptor and both enantiomers show additional weak activity at the histamine H1 and H2 receptors.

History GT-2203 was under development by Gliatech. It reached the preclinical research stage of development for insomnia and anxiety disorders prior to the discontinuation of its development in 2004. The drug was first described in the scientific literature by 1997. Aside from immethridine (BP-1-5375), GT-2203 is the only other selective histamine H3 receptor agonist to have been developed for potential pharmaceutical use.

See also BP 2.94 Cipralisant (GT-2331) Pitolisant SCH-50971

References

Illustrations

Worked examples

Example 1 — a first encounter with GT-2203

Start with the simplest possible case. Write down what GT-2203 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to GT-2203 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about GT-2203 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of GT-2203

In research: GT-2203 appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses GT-2203 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: GT-2203 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Amines, Cyclopropanes, Drugs not assigned an ATC code, so understanding it makes those chapters shorter.
In everyday life: Look for GT-2203 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study GT-2203 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what GT-2203 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain GT-2203 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is GT-2203 in simple terms?

Why does GT-2203 matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study GT-2203?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on GT-2203.