chemistry

GYKI-13380

GYKI-13380 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand GYKI-13380 rather than just read about it. In short: GYKI-13380 is an experimental appetite suppressant of the phenethylamine and amphetamine families which was never marketed. It is a cyclized phenethylamine, with the amine and α position of the side chain cyclized into an imidazolidinone moiety.

Key takeaways

GYKI-13380 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect GYKI-13380 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of GYKI-13380 from memory before moving on to harder problems.

Reference excerpt

GYKI-13380 is an experimental appetite suppressant of the phenethylamine and amphetamine families which was never marketed. It is a cyclized phenethylamine, with the amine and α position of the side chain cyclized into an imidazolidinone moiety. The drug potently suppresses appetite in rodents. It does not produce psychostimulant effects in rats, is not self-administered in rats, and does not produce pulmonary hypertension in dogs or cats. Instead, mild sedation was reported at relatively high doses. Accordingly, GYKI-13380 did not substitute for dextroamphetamine in rodent drug discrimination tests. On the other hand however, it fully substituted for fenfluramine in rodent drug discrimination tests. It is unclear whether GYKI-13380 and fenfluramine act via common mechanisms of action. It is known that GYKI-13380 may act in part as a phosphodiesterase inhibitor, but other potential actions of the drug, such as on the serotonin system, have not been evaluated. GYKI-13380 was first described in the literature in 1978 and was further described up to 1982. Subsequently, it was characterized and described in greater detail in 2022.

See also Substituted methoxyphenethylamine Cyclized phenethylamine APA-01 (PharmAla-1)

References

Illustrations

Worked examples

Example 1 — a first encounter with GYKI-13380

Start with the simplest possible case. Write down what GYKI-13380 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to GYKI-13380 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about GYKI-13380 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of GYKI-13380

In research: GYKI-13380 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses GYKI-13380 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: GYKI-13380 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Anorectics, Cyclopentanes, Drugs not assigned an ATC code, so understanding it makes those chapters shorter.
In everyday life: Look for GYKI-13380 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “GYKI-13380” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study GYKI-13380 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what GYKI-13380 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain GYKI-13380 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is GYKI-13380 in simple terms?

Why does GYKI-13380 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study GYKI-13380?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on GYKI-13380.