astronomy

Gabriella Campadelli-Fiume

Gabriella Campadelli-Fiume is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Gabriella Campadelli-Fiume rather than just read about it. In short: Gabriella Campadelli-Fiume is a virologist with a primary research focus on herpes simplex virus, fusion and viral entry. She is a retired professor of virology from the University of Bologna, Italy.

Key takeaways

Gabriella Campadelli-Fiume belongs to astronomy; place it in that map before memorising details.
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Reproduce the core statement of Gabriella Campadelli-Fiume from memory before moving on to harder problems.

Reference excerpt

Gabriella Campadelli-Fiume is a virologist with a primary research focus on herpes simplex virus, fusion and viral entry. She is a retired professor of virology from the University of Bologna, Italy.

Education and research Gabriella Campadelli-Fiume completed her doctorate of science (Sc.D.) at the University of Bologna, Italy. Her specialization in virology was also completed at the University of Bologna. Campadelli-Fiume primarily researches Herpes simplex virus (HSV), particularly how it enters, assembles, and exits the cell during an infection. In addition, she is interested in how HSV is induced to enter the exocytic pathway.

Primary focus

HSV entry into the cell Viral assembly in cell HSV exit out of the cell Viral induced alteration of exocytic pathway

Herpes simplex virus research Campadelli-Fiume's research primarily focuses on the entry mechanisms of both Herpes simplex virus 1 (HSV-1) and Herpes simplex virus 2 (HSV-2). Her work on these Group I double-stranded DNA viruses has centered on how they interact with host cell receptors to initiate infection. Specifically, her laboratory investigated the roles of specific viral glycoproteins, such as gD, gB, and the gH/gL complex—which are highly conserved across the Alphaherpesvirinae subfamily and serve as the core machinery for viral entry and cell-to-cell fusion.

Major discoveries Campadelli-Fiume's discovered that nectin is the host cell receptor for HSV. She also discovered the triggering activity of receptor- bound gD. In addition to these major discoveries, she identified the gF profusion domain, which provided the first evidence that retargeted HSVs exert anti-tumor activity.

Additional contributions to virology Gabriella Campadelli-Fiume took part in a study showing that glycoproteins gD, gB, and gH/gL permit herpes virus to enter cells and were involved in fusion. Their research indicated that gD is not required for the interactions between the glycoproteins gB and gH/gL. Rather, their interactions are made possible due to the multiple sites carried by gB. The multiple sites of gB can be found in the pleckstrin-domain that carries the bipartite fusion loop, and interaction with gH/gL can take place successfully without gD.

Influence Women have made significant progress towards equality within scientific fields of work. However, as efforts to increase women's participation in science fields, inequality exists. Furthermore, an underrepresented group of women remain in these fields. Campadelli-Fiume is an influential woman who continues to bridge the gender gap within the scientific community. Her achievements throughout her career have earned substantial amounts of attention and credible recognition globally. As the author of an overall encyclopedic of basic virology and clinical manifestations, Human Herpesviruses, her work has been included in the University of Pennsylvania’s 2007 Celebration of Women Writers. She has gained recent attention for laudable women in science by the International Society of Antiviral Research (ISAR) that has featured her as a prominent woman scientist. The American Academy of Microbiology awarded recognition of her scientific achievement and her contributions to advanced microbiology. Campadelli’s profound research, leadership principles, scientific achievements, and passion for virology, continue to convey a powerful impression to those within the scientific community. Her influence as a female scientist plays an important role to increasing the status of women in research.

Leadership Gabriella Campadelli-Fiume is an active member and leader in the scientific community.

Awards Accademia Nazionale dei Lincei, 2002 Pasteur Institute, Athens 1997 Fellowship in the American Academy of Microbiology

Editorial activity (2005–Present) Serves as an editorial board member for the Journal of Virology (2013–Present) Serves as an editorial board member for the Federation of European Microbiological Societies (FEMS) of Pathogens and Disease Serves on the International Advisory Board for The Lancet Journal

Scientific society and academy founder European Society for Virology Founding Member & Executive Board Member European Academy of Microbiology Founding Member Italian Society of Virology Founding Member

Committee service European Research Council DGXII Health Commissions Italian Ministry of Health Member of Health Research Committee from 2000-2006'

Major publications

Preclinical therapy of disseminated HER-2+ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus

Ichikawa K, Hughes IA, Horwitz AL, DeGroot LJ (1987). "Characterization of nuclear thyroid hormone receptors of cultured skin fibroblasts from patients with resistance to thyroid hormone". Metab. Clin. Exp. 36 (4): 392–9. doi:10.1016/0026-0495(87)90214-9. PMID 3561254. Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-κB

Singh GN, Gupta RP, Prakash P (1988). "Effect of ionic strength on the stability of norfloxacin". Pharmazie. 43 (2): 134. PMID 3393584. AlphaV-beta3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts

Chong YH, Soh CC (1966). "The protein nutritive quality of ikan bilis (Stolephorus spp.)". Med J Malaya. 20 (3): 230–3. PMID 4223072. Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain

Leonard, Fred (1989). "Butorphanol versus morphine: equally ineffective when given incorrectly". Ann Emerg Med. 18 (5): 603–5. doi:10.1016/s0196-0644(89)80869-8. PMID 2719377. Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2

Zora JA, Lutz CN, Tinkelman DG (1989). "Assessment of compliance in children using inhaled beta adrenergic agonists". Ann Allergy. 62 (5): 406–9. PMID 2566291. Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain

Leonard, Fred (1989). "Butorphanol versus morphine: equally ineffective when given incorrectly". Ann Emerg Med. 18 (5): 603–5. doi:10.1016/s0196-0644(89)80869-8. PMID 2719377. Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies

… excerpt ends here. Continue reading the full article.

Worked examples

Example 1 — a first encounter with Gabriella Campadelli-Fiume

Start with the simplest possible case. Write down what Gabriella Campadelli-Fiume claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Gabriella Campadelli-Fiume before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Gabriella Campadelli-Fiume ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Gabriella Campadelli-Fiume

In research: Gabriella Campadelli-Fiume appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Gabriella Campadelli-Fiume in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Gabriella Campadelli-Fiume is common in secondary-school and first-year university syllabi. It links to neighbouring topics 20th-century Italian scientists, 20th-century Italian women, 20th-century Italian women scientists, so understanding it makes those chapters shorter.
In everyday life: Look for Gabriella Campadelli-Fiume outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Gabriella Campadelli-Fiume in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Gabriella Campadelli-Fiume means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Gabriella Campadelli-Fiume out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Gabriella Campadelli-Fiume in simple terms?

Gabriella Campadelli-Fiume is a virologist with a primary research focus on herpes simplex virus, fusion and viral entry. She is a retired professor of virology from the University of Bologna, Italy.

Why does Gabriella Campadelli-Fiume matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Gabriella Campadelli-Fiume?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Gabriella Campadelli-Fiume.