chemistry

Gadopiclenol

Gadopiclenol is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Gadopiclenol rather than just read about it. In short: Gadopiclenol, sold under the brand name Elucirem or Vueway among others, is a contrast agent used with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system and in the body. Gadopiclenol is a paramagnetic macrocyclic non-ionic complex of gadolinium.

Key takeaways

Gadopiclenol belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Gadopiclenol to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Gadopiclenol from memory before moving on to harder problems.

Reference excerpt

Gadopiclenol, sold under the brand name Elucirem or Vueway among others, is a contrast agent used with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system and in the body. Gadopiclenol is a paramagnetic macrocyclic non-ionic complex of gadolinium. Gadopiclenol was approved for medical use in the United States in September 2022, and in the European Union in December 2023. Developed initially by Guerbet with intellectual property contributions from Bracco Imaging, gadopiclenol was commercialized following a strategic collaboration between the companies for manufacturing, research, and distribution.

Pharmacology Gadopiclenol has a higher relaxivity compared with standard gadolinium-based contrast agents (GBCAs). The higher relaxivity allows for a lower dose of gadopiclenol, reducing the total amount of gadolinium administered to the patient while preserving imaging quality. Gadopiclenol was approved by the FDA with a recommended dose of 0.05 mmol/kg for adults and pediatric patients aged 2 years and older. This is half the dose of standard macrocyclic GBCAs, which have a recommended dose of 0.1 mmol/kg.

Safety On 11/4/2025, the facility that manufactures Vueway and Elucirem's owner was sent an FDA Warning Letter for "significant violations of Current Good Manufacturing Practice (CGMP) regulations," notifying it that its "drug products are adulterated" and "Your firm released the above batches with OOS endotoxin failures for U.S. distribution." An €86 million investment to remedy the shortcomings that resulted in the failed FDA inspection and a €10 million destroyed inventory write off should allow manufacturing of Elucirem and Vueway to return to normal by 2027, after an anticipated positive FDA inspection in late 2026. Despite requiring half the dose of competitors, it carries a warning, like all GBCAs, which warns against intrathecal use, and mandates patient screening for kidney problems, that the recommended dose not be exceeded, and that sufficient time elapse for elimination before re-administration.

Society and culture

European Union Gadopiclenol was approved for medical use in the United States in September 2022 by the Food and Drug Administration. In October 2023, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Elucirem, intended for contrast-enhanced magnetic resonance imaging (MRI) to improve detection and, visualization of pathologies when diagnostic information is essential and not available with unenhanced MRI. The applicant for this medicinal product is Guerbet. In October and December 2023, the CHMP adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal products Elucirem and Vueway, intended for contrast-enhanced magnetic resonance imaging (MRI) to improve detection and, visualization of pathologies when diagnostic information is essential and not available with unenhanced MRI. Gadopiclenol was approved for medical use in the European Union in December 2023.

Brand names Gadopiclenol is the international nonproprietary name. Gadopiclenol is sold under the brand names Vueway and Elucirem.

References

External links Clinical trial number NCT03996447 for "Efficacy and Safety of Gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI) (PICTURE)" at ClinicalTrials.gov Clinical trial number NCT03986138 for "Efficacy and Safety of Gadopiclenol for Body Magnetic Resonance Imaging (MRI) (PROMISE)" at ClinicalTrials.gov

Illustrations

Worked examples

Example 1 — a first encounter with Gadopiclenol

Start with the simplest possible case. Write down what Gadopiclenol claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Gadopiclenol before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Gadopiclenol ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Gadopiclenol

In research: Gadopiclenol appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Gadopiclenol in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Gadopiclenol is common in secondary-school and first-year university syllabi. It links to neighbouring topics Amides, Carboxylic acids, Gadolinium-based MRI contrast agents, so understanding it makes those chapters shorter.
In everyday life: Look for Gadopiclenol outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Gadopiclenol in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Gadopiclenol means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Gadopiclenol out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Gadopiclenol in simple terms?

Why does Gadopiclenol matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Gadopiclenol?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Gadopiclenol.