biology

Giovanna Tosato

Giovanna Tosato is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Giovanna Tosato rather than just read about it. In short: Giovanna Tosato (born c. 1949) is an Italian–American physician-scientist and cancer researcher investigating the endothelium, angiogenesis, and the hematopoietic stem cell niche. She heads the molecular and cell biology section in the laboratory of cellular oncology at the National Cancer Institute in the United States.

Key takeaways

Giovanna Tosato belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Giovanna Tosato to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Giovanna Tosato from memory before moving on to harder problems.

Reference excerpt

Giovanna Tosato (born c. 1949) is an Italian–American physician-scientist and cancer researcher investigating the endothelium, angiogenesis, and the hematopoietic stem cell niche. She heads the molecular and cell biology section in the laboratory of cellular oncology at the National Cancer Institute in the United States. Tosato was a division director in the Center for Biologics Evaluation and Research from 1992 to 1999.

Education Tosato was born c. 1949. She earned an M.D. at the Sapienza University of Rome in 1973. She completed a residency at the Catholic University in Rome. In 1976, she moved to the National Cancer Institute (NCI) in the United States where she became a clinical associate in the pediatric and medicine branches and subsequently a visiting fellow in the metabolism branch. In 1982, work performed by Tosato, Alfred Steinberg, and Michael Blaese showed an association between a particular viral infection and rheumatoid arthritis.

Career and research In 1983, Tosato began working at the United States Food and Drug Administration (FDA). From 1992 to 1999 she served as director of the Center for Biologics Evaluation and Research's division of hematologic products, center for biologics evaluation and research. In 1999, Tosato returned to the NCI as a senior investigator. As of 2021, she heads the molecular and cell biology section in the laboratory of cellular oncology at the National Cancer Institute. Tosato's laboratory focuses on the study of the endothelium in the context of cancer development and progression. She studies angiogenesis and vessel survival as these processes are essential for tumor growth. Her laboratory investigates the endothelium as a component of the hematopoietic cell niche. This research is used to develop targeted therapies for cancer and other conditions in which the endothelium plays a functional role.

Personal life At the age of 64, Tosato completed the 2013 Boston Marathon in 3 hours and 57 minutes. She was between 50 and 100 yards past the finish line when the Boston Marathon bombing started.

Selected works Tosato, G; Jones, Kd (March 1990). "Interleukin-1 induces interleukin-6 production in peripheral blood monocytes". Blood. 75 (6): 1305–1310. doi:10.1182/blood.V75.6.1305.1305. ISSN 0006-4971. PMID 2310829. Taga, K; Mostowski, H; Tosato, G (June 1993). "Human interleukin-10 can directly inhibit T-cell growth". Blood. 81 (11): 2964–2971. doi:10.1182/blood.V81.11.2964.2964. ISSN 0006-4971. PMID 8499633. Angiolillo, A L; Sgadari, C; Taub, D D; Liao, F; Farber, J M; Maheshwari, S; Kleinman, H K; Reaman, G H; Tosato, G (July 1995). "Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo". Journal of Experimental Medicine. 182 (1): 155–162. doi:10.1084/jem.182.1.155. ISSN 0022-1007. PMC 2192108. PMID 7540647. Sgadari, C; Angiolillo, Al; Tosato, G (May 1996). "Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10". Blood. 87 (9): 3877–3882. doi:10.1182/blood.V87.9.3877.bloodjournal8793877. ISSN 0006-4971. PMID 8611715.

References

Illustrations

Worked examples

Example 1 — a first encounter with Giovanna Tosato

Start with the simplest possible case. Write down what Giovanna Tosato claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Giovanna Tosato before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Giovanna Tosato ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Giovanna Tosato

In research: Giovanna Tosato appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Giovanna Tosato in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Giovanna Tosato is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1940s births, 20th-century American biologists, 20th-century American women biologists, so understanding it makes those chapters shorter.
In everyday life: Look for Giovanna Tosato outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Giovanna Tosato in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Giovanna Tosato means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Giovanna Tosato out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Giovanna Tosato in simple terms?

Why does Giovanna Tosato matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Giovanna Tosato?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Giovanna Tosato.