Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix. The tumour gets its name from its microscopic appearance; its cytoplasm has a glass-like appearance.
Signs and symptoms The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.
Cause
Diagnosis The diagnosis is based on tissue examination, e.g. biopsy. Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated with an inflammatory infiltrate abundant in eosinophils and very mitotically active. PAS staining highlights the plasma membrane.
Treatment The treatment is dependent on the stage. Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and chemotherapy.
See also Cervix Cervical cancer Villoglandular adenocarcinoma
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References
Further reading Greer, Benjamin E.; Koh, Wui-Jin; Abu-Rustum, Nadeem; Bookman, Michael A.; Bristow, Robert E.; Campos, Susana M.; Cho, Kathleen R.; Copeland, Larry; Crispens, Marta Ann; Eifel, Patricia J.; Huh, Warner K.; Jaggernauth, Wainwright; Kapp, Daniel S.; Kavanagh, John J.; Lurain, John R.; Morgan, Mark; Morgan, Robert J.; Powell, C. Bethan; Remmenga, Steven W.; Reynolds, R. Kevin; Secord, Angeles Alvarez; Small, William; Teng, Nelson (1 May 2009). "Uterine Neoplasms". Journal of the National Comprehensive Cancer Network. 7 (5): 498–531. doi:10.6004/jnccn.2009.0035. ISSN 1540-1405. PMID 19460278. Retrieved 19 July 2017.
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