science

GlobeImmune

GlobeImmune is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand GlobeImmune rather than just read about it. In short: GlobeImmune, Inc. is a clinical-stage public biopharmaceutical company headquartered in Louisville, Colorado, that develops therapeutic vaccines to treat cancer and infectious diseases. As of August 2014, the company had no marketed products.

Key takeaways

GlobeImmune belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect GlobeImmune to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of GlobeImmune from memory before moving on to harder problems.

Reference excerpt

GlobeImmune, Inc. is a clinical-stage public biopharmaceutical company headquartered in Louisville, Colorado, that develops therapeutic vaccines to treat cancer and infectious diseases. As of August 2014, the company had no marketed products. GlobeImmune’s therapeutic vaccines are developed on the company’s Tarmogen immunotherapy platform. Tarmogens are made from genetically modified yeast that express one or more disease-associated antigens. Tarmogens activate T cells to specifically target and eliminate diseased cells with the same target antigen.

The company has partnerships with Celgene (established in 2009) and the National Cancer Institute for the development of cancer vaccines. Their collaboration with Gilead for the development of therapeutic vaccines for the treatment of hepatitis B was terminated in November 2016 after the product they were developing failed a clinical trial the year before. With respect to financing in the absence of revenue, the company raised US$17,500,000 through a Series E Preferred Stock offering in January 2010. As of August 2015, GlobeImmune had two therapeutic vaccines in clinical trials, GI-6207 and GI-6301, for the treatment of various cancers. Completed trials have addressed two other candidates, GI-4000 (the company's lead oncology candidate as of 2010) and GI-5005. Despite there being three ongoing trials, in July 2015 the company announced it would eliminate "most of its workforce positions" shortly following the failure of a trial examining GI-4774. In March 2017, GlobeImmune announced that it has entered into a definitive purchase agreement for the sale of shares of its common stock to NantCell, Inc.

References

External links GlobeImmune website Archived 2012-03-22 at the Wayback Machine

Illustrations

Worked examples

Example 1 — a first encounter with GlobeImmune

Start with the simplest possible case. Write down what GlobeImmune claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to GlobeImmune before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about GlobeImmune ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of GlobeImmune

In research: GlobeImmune appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses GlobeImmune in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: GlobeImmune is common in secondary-school and first-year university syllabi. It links to neighbouring topics Biotechnology companies of the United States, Companies based in Boulder County, Colorado, Companies listed on the Nasdaq, so understanding it makes those chapters shorter.
In everyday life: Look for GlobeImmune outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study GlobeImmune in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what GlobeImmune means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain GlobeImmune out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is GlobeImmune in simple terms?

Why does GlobeImmune matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study GlobeImmune?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on GlobeImmune.