In enzymology, a gluconate 2-dehydrogenase (EC 1.1.1.215) is an enzyme that catalyzes the chemical reaction
D-gluconate + NADP+ ⇌ {\displaystyle \rightleftharpoons } 2-dehydro-D-gluconate + NADPH + H+ Thus, the two substrates of this enzyme are D-gluconate and NADP+, whereas its 3 products are 2-dehydro-D-gluconate, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-gluconate:NADP+ oxidoreductase. Other names in common use include 2-keto-D-gluconate reductase, and 2-ketogluconate reductase.
References
Ameyama M (1978). "Crystalline 2-ketogluconate reductase from Acetobacter ascendens, the second instance of crystalline enzyme in genus Acetobacter". Agric. Biol. Chem. 42 (11): 2057–2062. doi:10.1271/bbb1961.42.2057. Chiyonobu T, Shinagawa E, Adachi O, Ameyama M (1976). "Purification, crystallization and properties of 2-ketogluconate reductase from Acetobacter rancens". Agric. Biol. Chem. 40: 175–184. doi:10.1271/bbb1961.40.175.
