The enzyme gluconate dehydratase (EC 4.2.1.39) catalyzes the chemical reaction
D-gluconate ⇌ {\displaystyle \rightleftharpoons } 2-dehydro-3-deoxy-D-gluconate + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in the pentose phosphate pathway.
Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1QJ4.
References
Andreesen JR, Gottschalk G (1969). "The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum". Arch. Mikrobiol. 69 (2): 160–70. Bibcode:1969ArMic..69..160A. doi:10.1007/BF00409760. PMID 5383859. S2CID 19210429.
