engineering

Glucose 1-dehydrogenase

Glucose 1-dehydrogenase is a engineering topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Glucose 1-dehydrogenase rather than just read about it. In short: In enzymology, glucose 1-dehydrogenase (EC 1.1.1.47) is an enzyme that catalyzes the chemical reaction The two substrates of this enzyme are β-D-glucose and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are D-glucono-1,5-lactone, reduced NADH, and a proton.

Key takeaways

Glucose 1-dehydrogenase belongs to engineering; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Glucose 1-dehydrogenase to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Glucose 1-dehydrogenase from memory before moving on to harder problems.

Reference excerpt

In enzymology, glucose 1-dehydrogenase (EC 1.1.1.47) is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are β-D-glucose and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are D-glucono-1,5-lactone, reduced NADH, and a proton. The enzyme can alternatively use nicotinamide adenine dinucleotide phosphate (NADP+) for oxidation and in that case produces NADPH. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)+ 1-oxidoreductase. Another name in common use is D-glucose dehydrogenase (NAD(P)+).

Structural studies As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1G6K, PDB: 1GCO, PDB: 1GEE, PDB: 1RWB, PDB: 1SPX, PDB: 2B5V, PDB: 2B5W, PDB: 2CD9, and PDB: 2CDA.

References

Banauch D, Brümmer W, Ebeling W, Metz H, Rindfrey H, Lang H, Leybold K, Rick W, Staudinger HJ (1975). "[A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)]". Z. Klin. Chem. Klin. Biochem. 13 (3): 101–7. PMID 810982. Brink NG; Miettinen, Jorma K.; Olsen, John; Virtanen, Artturi I.; Sörensen, Nils Andreas (1953). "Beef liver glucose dehydrogenase. 1. Purification and properties". Acta Chem. Scand. 7: 1081–1089. doi:10.3891/acta.chem.scand.07-1081. Pauly HE, Pfleiderer G (1976). "D-Glucose dehydrogenase from Bacillus megaterium M 1286: purification, properties and structure". Hoppe-Seyler's Z. Physiol. Chem. 356 (10): 1613–1623. doi:10.1515/bchm2.1975.356.2.1613. PMID 2530. Strecker HJ, Korkes S (1952). "Glucose dehydrogenase". J. Biol. Chem. 196 (2): 769–84. doi:10.1016/S0021-9258(19)52408-5. PMID 12981017. Thompson RE, Carper WR (1970). "Glucose dehydrogenase from pig liver. I. Isolation and purification". Biochim. Biophys. Acta. 198 (3): 397–406. doi:10.1016/0005-2744(70)90118-x. PMID 4392298.

Illustrations

Worked examples

Example 1 — a first encounter with Glucose 1-dehydrogenase

Start with the simplest possible case. Write down what Glucose 1-dehydrogenase claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In engineering, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Glucose 1-dehydrogenase before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Glucose 1-dehydrogenase ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Glucose 1-dehydrogenase

In research: Glucose 1-dehydrogenase appears in engineering research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Glucose 1-dehydrogenase in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Glucose 1-dehydrogenase is common in secondary-school and first-year university syllabi. It links to neighbouring topics EC 1.1.1, EC 1.1.1 stubs, Enzymes of known structure, so understanding it makes those chapters shorter.
In everyday life: Look for Glucose 1-dehydrogenase outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Glucose 1-dehydrogenase in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Glucose 1-dehydrogenase means in your own words.
Compare your version with the excerpt and mark what you missed.
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Frequently asked questions

What is Glucose 1-dehydrogenase in simple terms?

In enzymology, glucose 1-dehydrogenase (EC 1.1.1.47) is an enzyme that catalyzes the chemical reaction The two substrates of this enzyme are β-D-glucose and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are D-glucono-1,5-lactone, reduced NADH, and a proton.

Why does Glucose 1-dehydrogenase matter?

Because it connects several engineering ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Glucose 1-dehydrogenase?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Glucose 1-dehydrogenase.