Glyceollin III is a glyceollin, a type of pterocarpan, found in the soybean (Glycine max). It has an antiestrogenic effect in vivo. In soil, it has an antifungal activity against Aspergillus sojae.
Biosynthesis All the glyceollins are products of a pathway in soybean which starts from the amino acid L-phenylalanine. This is converted in a series of steps to the flavanone, liquiritigenin, and then by the action of isoflavonoid synthase (IFS) to the isoflavone, daidzein.
A further sequence of four enzyme-catalysed reactions creates the pterocarpan ring system of the compound glycinol. The prenylation enzyme trihydroxypterocarpan dimethylallyltransferase (G4DT) and then glyceollin synthase (GS) complete the biosynthesis of glyceollin III.
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