The enzyme glycerol-1-phosphatase (EC 3.1.3.21) catalyzes the reaction
The enzyme characterised from Dunaliella salina hydrolyses racemic glycerol 3-phosphate to glycerol and orthophosphate. Among the organisms that have been shown to express this enzymatic activity are Arabidopsis thaliana (plant) via the AtSgpp and AtGpp gene products; Dunaliella salina (alga); Saccharomyces cerevisiae (fungus) via the GPP1/RHR2/YIL053W and GPP2/HOR2/YER062C gene products; Candida albicans (fungus) via the GPP1 gene product; Mycobacterium tuberculosis (bacteria) via the rv1692 gene product; and C57BL/6N mice and Wistar rats (mammals) via the PGP gene product.
Nomenclature This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is glycerol-1-phosphate phosphohydrolase. Other names in common use include α-glycerophosphatase, α-glycerol phosphatase, glycerol 3-phosphatase, glycerol-3-phosphate phosphatase, and glycerol 3-phosphate phosphohydrolase.
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