The enzyme glycerophosphocholine phosphodiesterase (EC 3.1.4.2) catalyzes the reaction
The enzyme characterised from bacteria and liver hydrolyses glycerophosphorylcholine to its components (R)-glyceryl 1-phosphate and choline. Glycerophosphorylcholine is an osmolyte and this enzyme regulates its level. The glycerophosphocholine pathway of which this is a part is implicated in carcinogenesis and tumor progression. This enzyme is a hydrolase, specifically one acting on phosphoric diester bonds. The systematic name is sn-glycero-3-phosphocholine glycerophosphohydrolase. Other names in common use include glycerophosphinicocholine diesterase, glycerylphosphorylcholinediesterase, sn-glycero-3-phosphorylcholine diesterase, glycerolphosphorylcholine phosphodiesterase, and glycerophosphohydrolase.
See also Glycerophosphocholine cholinephosphodiesterase which hydrolyses glycerophosphorylcholine to glycerol and choline phosphate
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