The enzyme glycerophosphoinositol inositolphosphodiesterase (EC 3.1.4.43) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from rat kidney hydrolyses 1-(sn-glycero-3-phospho)-1D-myo-inositol to its components glycerol and inositol monophosphate. The compound 1D-myo-inositol 1,2-cyclic phosphate is also a substrate for the enzyme and is converted to the same product as the linear phosphate diester. The protein making up the enzyme is also called lipocortin III or annexin III:
However, a later X-ray crystallography study demonstrated that annexin III did not possess any enzymatic activity.
Nomenclature This enzyme is a hydrolase, specifically one acting on phosphoric diester bonds. The systematic name is 1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase. Other names in common use include 1,2-cyclic-inositol-phosphate phosphodiesterase, D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase, D-inositol 1,2-cyclic phosphate 2-phosphohydrolase, D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase, 1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase, and inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase.
See also Glycerophosphoinositol glycerophosphodiesterase which hydrolyses 1-(sn-glycero-3-phospho)-1D-myo-inositol to give sn-glycerol 3-phosphate and myo-inositol
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