Glycine receptor subunit alpha-1 is a protein that in humans is encoded by the GLRA1 gene.
Function The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed solely of alpha subunits. The GLRB gene encodes the alpha subunit of the receptor.
Clinical significance Mutations in the gene have been associated with hyperekplexia, a neurologic syndrome associated with an exaggerated startle reaction.
See also Glycine receptor Stiff person syndrome Hyperekplexia
References
Further reading
External links Overview of all the structural information available in the PDB for UniProt: P23415 (Glycine receptor subunit alpha-1) at the PDBe-KB. This article incorporates text from the United States National Library of Medicine, which is in the public domain.






