In enzymology, glyoxylate reductase (NADP+) (EC 1.1.1.79) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are glycolic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are glyoxylic acid, reduced NADPH, and a proton. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolate:NADP+ oxidoreductase. Other names in common use include NADPH-glyoxylate reductase, and glyoxylate reductase (NADP+). This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.
Structural studies As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB: 2GCG, PDB: 2H1S, and PDB: 2Q50.
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