chemistry

Grahame Hardie

Grahame Hardie is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Grahame Hardie rather than just read about it. In short: David Grahame Hardie (born 1950) is a Scottish biochemist, and Professor of Cellular Signalling, at the School of Life Sciences, University of Dundee. Career and research He was a member of the Faculty of 1000.

Key takeaways

Grahame Hardie belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Grahame Hardie to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Grahame Hardie from memory before moving on to harder problems.

Reference excerpt

David Grahame Hardie (born 1950) is a Scottish biochemist, and Professor of Cellular Signalling, at the School of Life Sciences, University of Dundee.

Career and research He was a member of the Faculty of 1000. He is known for the discovery of AMP-activated protein kinase (AMPK).

Publications "Regulation of AMP-activated protein kinase by natural and synthetic activators", Acta Pharmaceutica Sinica B (2016) 6, (1–19) "AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer", Biochemical Society Transactions (2011) 39, (1–13) D. Grahame Hardie, ed. (1999). "Analysis of signal transduction pathways using protein serine - threonine phosphate inhibitors". Protein phosphorylation: a practical approach. Oxford University Press. ISBN 978-0-19-963729-4. Biochemical messengers: hormones, neurotransmitters, and growth factors. Springer. 1991. ISBN 978-0-412-30350-0.

References

External links https://www.biomedcentral.com/authors/profiles/grahamehardie https://web.archive.org/web/20120426072341/http://mediacentral.cshl.edu/Symposium76/Symposium76/Interviews/Entries/2011/6/5_Grahame_Hardie.html https://homecomingscotlandblog.blogspot.com/2008/10/professor-grahame-hardie-frs-frse.html

Worked examples

Example 1 — a first encounter with Grahame Hardie

Start with the simplest possible case. Write down what Grahame Hardie claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Grahame Hardie before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Grahame Hardie ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Grahame Hardie

In research: Grahame Hardie appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Grahame Hardie in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Grahame Hardie is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1950 births, Academics of the University of Dundee, Biochemist stubs, so understanding it makes those chapters shorter.
In everyday life: Look for Grahame Hardie outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Grahame Hardie in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Grahame Hardie means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Grahame Hardie out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Grahame Hardie in simple terms?

David Grahame Hardie (born 1950) is a Scottish biochemist, and Professor of Cellular Signalling, at the School of Life Sciences, University of Dundee. Career and research He was a member of the Faculty of 1000.

Why does Grahame Hardie matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Grahame Hardie?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Grahame Hardie.