In molecular biology, group II pyridoxal-dependent decarboxylases are a family of enzymes including aromatic-L-amino-acid decarboxylase (L-dopa decarboxylase or tryptophan decarboxylase) EC 4.1.1.28 that catalyse the decarboxylation of tryptophan to tryptamine, tyrosine decarboxylase EC 4.1.1.25 that converts tyrosine into tyramine and histidine decarboxylase EC 4.1.1.22 that catalyses the decarboxylation of histidine to histamine. Pyridoxal-5'-phosphate-dependent amino acid decarboxylases can be divided into four groups based on amino acid sequence: group II includes glutamate, histidine, tyrosine, and aromatic-L-amino-acid decarboxylases.
See also Group I pyridoxal-dependent decarboxylases Group III pyridoxal-dependent decarboxylases Group IV pyridoxal-dependent decarboxylases
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