Guanylate cyclase activator 2B is a protein that in humans is encoded by the GUCA2B gene.
Function This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.





