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biology

H295R

H295R is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand H295R rather than just read about it. In short: H295R (also referred to as NCI-H295R) is an angiotensin-II-responsive steroid-producing adrenocortical cell line. It was initially isolated in 1980 from a 48-year-old female patient diagnosed with adrenocortical carcinoma.

Key takeaways

  • H295R belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect H295R to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of H295R from memory before moving on to harder problems.

Reference excerpt

H295R (also referred to as NCI-H295R) is an angiotensin-II-responsive steroid-producing adrenocortical cell line. It was initially isolated in 1980 from a 48-year-old female patient diagnosed with adrenocortical carcinoma. The initial polyclonal populations of tumor cells obtained from the patients' tumor were cultured and the resultant cell line was called NCI-H295. Because of slow growth rates and easy detachment of the original NCI-H295 strains, efforts were made to select a population of cells with better monolayer attachment and more rapid growth. Three strains were developed, based on the serum supplement used for growth, which have been termed H295R-S1, H295R-S2 and H295R-S3. All three strains grow as adherent monolayer cultures.

References

External links Cellosaurus entry for H295R

Worked examples

Example 1 — a first encounter with H295R

Start with the simplest possible case. Write down what H295R claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to H295R before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about H295R ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of H295R

In research
H295R appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses H295R in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
H295R is common in secondary-school and first-year university syllabi. It links to neighbouring topics Adrenal gland, Adrenocortical carcinoma cell lines, Cancer cell lines, so understanding it makes those chapters shorter.
In everyday life
Look for H295R outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study H295R in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what H295R means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain H295R out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is H295R in simple terms?

H295R (also referred to as NCI-H295R) is an angiotensin-II-responsive steroid-producing adrenocortical cell line. It was initially isolated in 1980 from a 48-year-old female patient diagnosed with adrenocortical carcinoma.

Why does H295R matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study H295R?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on H295R.

Tags

  • Adrenal gland
  • Adrenocortical carcinoma cell lines
  • Cancer cell lines
  • Endocrinology
  • Human cell lines
  • Steroid hormones

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