2-hydroxyacyl-CoA lyase 1 is a protein that in humans is encoded by the HACL1 gene. It produces a 2-Hydroxyphytanoyl-CoA lyase.
Function The product is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor. The corresponding EC number is 4.1.2.63.
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