In enzymology, a hexaprenyldihydroxybenzoate methyltransferase (EC 2.1.1.114) is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate Thus, the two substrates of this enzyme are S-adenosyl methionine and 3-hexaprenyl-4,5-dihydroxybenzoate, whereas its two products are S-adenosylhomocysteine and 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase. Other names in common use include 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, and dihydroxyhexaprenylbenzoate methyltransferase. This enzyme participates in ubiquinone biosynthesis.
References
Clarke CF, Williams W, Teruya JH (1991). "Ubiquinone biosynthesis in Saccharomyces cerevisiae. Isolation and sequence of COQ3, the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene". J. Biol. Chem. 266 (25): 16636–44. doi:10.1016/S0021-9258(18)55349-7. PMID 1885593.
