Hexoprenaline is a selective β2 adrenergic receptor agonist used in the treatment of asthma. Hexoprenaline is also used in some countries (such as Russia and Switzerland) as a tocolytic agent (i.e., labor suppressant), with the most common trade name being Gynipral. It is not approved by the United States Food and Drug Administration.
Contraindications When used as a tocolytic, hexoprenaline is contraindicated in:
Hyperthyroidism Cardiovascular diseases, e.g. cardiac arrhythmias, tachycardia, myocarditis, mitral valve disease and aortic stenosis Ischemic heart disease Hypertension Angle-closure glaucoma Placental abruption, vaginal bleeding and inflammatory diseases of internal genitalia (such as endometritis) Shock First trimester of pregnancy Breastfeeding It should be used with caution in people with gestational diabetes.
Drug-drug interactions When concomitantly administered:
Beta blockers reduce or neutralize therapeutic effects of hexoprenaline Methylxanthines (caffeine, theobromine, theophylline) increase its action General anaesthetics (e.g., halothane) and adrenergic receptor agonists may increase the risk of cardiovascular side effects, such as arrhythmia Hexoprenaline is contraindicated for use with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressant (TCAs), ergot alkaloids, and dihydrotachysterol.
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