The enzyme histidinol-phosphatase (EC 3.1.3.15) catalyzes the reaction
The enzyme characterised from Neurospora crassa hydrolyses L-histidinol phosphate to histidinol and orthophosphate. The reaction is part of the biosynthesis of the amino acid histidine.
Nomenclature This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is L-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, L-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase.
E. coli
In E. coli the enzyme encoded by the gene hisB is a fused imidazoleglycerol-phosphate dehydratase and histidinol-phosphatase.
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