engineering

Histidinol-phosphate transaminase

Histidinol-phosphate transaminase is a engineering topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Histidinol-phosphate transaminase rather than just read about it. In short: Histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the reversible chemical reaction The enzyme first characterised from Neurospora crassa converts 3-(imidazol-4-yl)-2-oxopropyl phosphate to L-histidinol phosphate (a precursor to the amino acid histidine) using L-glutamic acid as the source of the amino group that is transferred. It uses pyridoxal phosphate as a cofactor and has also been foun…

Key takeaways

Histidinol-phosphate transaminase belongs to engineering; place it in that map before memorising details.
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Reference excerpt

Histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the reversible chemical reaction

The enzyme first characterised from Neurospora crassa converts 3-(imidazol-4-yl)-2-oxopropyl phosphate to L-histidinol phosphate (a precursor to the amino acid histidine) using L-glutamic acid as the source of the amino group that is transferred. It uses pyridoxal phosphate as a cofactor and has also been found in Salmonella typhimurium. This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-histidinol-phosphate:2-oxoglutarate aminotransferase. Other names in common use include imidazolylacetolphosphate transaminase, glutamic-imidazoleacetol phosphate transaminase, histidinol phosphate aminotransferase, imidazoleacetol phosphate transaminase, L-histidinol phosphate aminotransferase, histidine:imidazoleacetol phosphate transaminase, IAP transaminase, and imidazolylacetolphosphate aminotransferase. It participates in five metabolic pathways: histidine metabolism, tyrosine metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and novobiocin biosynthesis.

Structural studies As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1FG3, PDB: 1FG7, PDB: 1GEW, PDB: 1GEX, PDB: 1GEY, PDB: 1H1C, PDB: 1IJI, PDB: 1UU0, PDB: 1UU1, PDB: 1UU2, and PDB: 2F8J.

References

Illustrations

Worked examples

Example 1 — a first encounter with Histidinol-phosphate transaminase

Start with the simplest possible case. Write down what Histidinol-phosphate transaminase claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In engineering, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Histidinol-phosphate transaminase before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Histidinol-phosphate transaminase ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Histidinol-phosphate transaminase

In research: Histidinol-phosphate transaminase appears in engineering research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Histidinol-phosphate transaminase in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Histidinol-phosphate transaminase is common in secondary-school and first-year university syllabi. It links to neighbouring topics EC 2.6.1, EC 2.6 stubs, Enzymes of known structure, so understanding it makes those chapters shorter.
In everyday life: Look for Histidinol-phosphate transaminase outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

What is Histidinol-phosphate transaminase in simple terms?

Histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the reversible chemical reaction The enzyme first characterised from Neurospora crassa converts 3-(imidazol-4-yl)-2-oxopropyl phosphate to L-histidinol phosphate (a precursor to the amino acid histidine) using L-glutamic aci…

Why does Histidinol-phosphate transaminase matter?

Because it connects several engineering ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Histidinol-phosphate transaminase?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Histidinol-phosphate transaminase.