The history of smallpox in Mexico spans approximately 430 years, from the Spanish invasion and colonization of Central America until its official eradication under the Republic of Mexico in 1951. It was brought to what is now Mexico by the Spanish conquistadores, then spread to the center of Mexico, where it became a significant factor in the fall of Tenochtitlan. During the colonial period, there were major epidemic outbreaks which led to the implementation of sanitary and preventive policy. The introduction of smallpox vaccination in New Spain by Francisco Javier de Balmis and the work of Ignacio Bartolache reduced the mortality and morbidity of the disease.
Introduction of smallpox
Smallpox was an unknown disease not only in the Aztec Empire but in all the American continent, before the European colonization of the Americas (15th century onwards). Indigenous peoples of the Americas had not yet been exposed to the type of diseases that plagued the East, which meant that they had no resistance or immunity against them. It was introduced to Mexican lands by the Spanish conquistadores, and played a significant role in the downfall of the Aztec Empire (1519–1530). Hernán Cortés departed from Spanish-ruled colonial Cuba and arrived in Mexico in 1519, sent to start trade relations only on the coast of Veracruz. However, he disobeyed the Cuban governor Diego Velázquez de Cuéllar and began to invade the mainland. The governor sent Pánfilo de Narváez after Cortés. Narvaez's forces had at least one active case of smallpox infection, and when the Narvaez expedition stopped at Cozumel and Veracruz in 1520, the disease gained a foothold in the region. The introduction of smallpox among the Aztecs has been attributed to an African slave trafficked by the Spanish colonizers (by the name of Francisco Eguía, according to one account), but this has been disputed. From May to September, smallpox spread slowly to Tepeaca and Tlaxcala, and to Tenochtitlán by the fall of 1520. At this time, Cortes was returning to conquer the city after being thrown out on the Noche Triste. Cortes names only one indigenous leader who died of smallpox, Maxixcatzin. However, Cuitláhuac and other native rulers also died of smallpox. Chimalpahin reports the death of some lords in Chalco from the disease as well. These deaths were part of a widespread epidemic which devastated the common population. Estimates of mortality range from one-quarter to one-half of the population of central Mexico. Toribio Motolinia, a Spanish Roman Catholic monk that witnessed this epidemic, said: "It became such a great pestilence among them throughout the land that in most provinces more than half the population died; in others the proportion was less. They died in heaps, like bedbugs." It had been estimated that the population of Mexico fell from over thirty million people before the arrival of Hernan Cortez to 1.5–3 million by 1568. Although the numbers are uncertain, it is estimated that smallpox killed forty to fifty million people in the New World. Regardless of the exact numbers, it is certain that the conquest of the Aztec Empire was greatly influenced by the arrival of the smallpox virus.
Major outbreaks in the colonial period
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![History of smallpox in Mexico: Population collapse in the history of Mexico (16th–17th centuries), attributed to repeated epidemics of smallpox and cocoliztli viruses.[1] The viral outbreaks were caused by the Spanish invasion and colonization of Central America.[1]](https://upload.wikimedia.org/wikipedia/commons/thumb/5/56/Acuna-Soto_EID-v8n4p360_Fig1.png/500px-Acuna-Soto_EID-v8n4p360_Fig1.png?utm_source=en.wikipedia.org&utm_campaign=parser&utm_content=thumbnail)
