biology

Human Proteinpedia

Human Proteinpedia is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Human Proteinpedia rather than just read about it. In short: Human Proteinpedia, which is closely associated with Institute of Bioinformatics (IOB), Bangalore and Johns Hopkins University, is a portal for sharing and integration of human proteomic data. It allows research laboratories to contribute and maintain protein annotations.

Key takeaways

Human Proteinpedia belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Human Proteinpedia to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Human Proteinpedia from memory before moving on to harder problems.

Reference excerpt

Human Proteinpedia, which is closely associated with Institute of Bioinformatics (IOB), Bangalore and Johns Hopkins University, is a portal for sharing and integration of human proteomic data. It allows research laboratories to contribute and maintain protein annotations. Human Protein Reference Database (HPRD) integrates data, that is deposited in Human Proteinpedia along with the existing literature curated information at the context of an individual protein. In essence, researchers can add new data to HPRD by registering to Human Proteinpedia. The data deposited in Human Proteinpedia is freely available for download. Emphasizing the importance of proteomics data disposition to public repositories, Nature Methods recommends Human Proteinpedia in their editorial. More than 70 labs participate in this effort.

Data types Data pertaining to post-translational modifications, protein–protein interactions, tissue expression, expression in cell lines, subcellular localization and enzyme substrate relationships can be submitted to Human Proteinpedia.

Experimental platforms Protein annotations present in Human Proteinpedia are derived from a number of platforms such as

Co-immunoprecipitation and mass spectrometry-based protein–protein interaction Co-immunoprecipitation and Western blotting based protein–protein interaction Fluorescence based experiments Immunohistochemistry Mass spectrometric analysis Protein and peptide microarrays Western blotting Yeast two-hybrid based protein–protein interaction This portal that allows adding of protein information was developed as a collaborative effort between the laboratory of Dr. Akhilesh Pandey at Johns Hopkins University and the Institute of Bioinformatics.

FAQs * What are the criteria for contributing data? Any investigator who fulfills the following criteria can contribute data: i) provides experimentally derived data, and, ii) is willing to share data, and, iii) is willing to be listed as the 'contributor' of the data * Can I contribute data anonymously? Anonymous contributions are not allowed. Contributor details should be clearly presented while contributing data. * Can bioinformatically predicted data be shared through Human Proteinpedia? Predictions of any type are not allowed. Contributed data should be derived experimentally and should be accompanied with experimental evidence. * Is the contributed data subjected to peer review? The data are not subjected to peer review and the actual experimental data (raw or processed) should be provided. * What will happen to conflicting results from different laboratories? In cases where a given entry is documented as erroneous, we will consult with the contributing group(s) about deleting the entry.

External links humanproteinpedia.org Archived March 14, 2007, at the Wayback Machine www.hprd.org Archived April 24, 2006, at the Wayback Machine

References

Worked examples

Example 1 — a first encounter with Human Proteinpedia

Start with the simplest possible case. Write down what Human Proteinpedia claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Human Proteinpedia before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Human Proteinpedia ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Human Proteinpedia

In research: Human Proteinpedia appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Human Proteinpedia in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Human Proteinpedia is common in secondary-school and first-year university syllabi. It links to neighbouring topics Bioinformatics, Proteomics, so understanding it makes those chapters shorter.
In everyday life: Look for Human Proteinpedia outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Human Proteinpedia in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Human Proteinpedia means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Human Proteinpedia out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Human Proteinpedia in simple terms?

Why does Human Proteinpedia matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Human Proteinpedia?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Human Proteinpedia.