biology

Human Variome Project

Human Variome Project is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Human Variome Project rather than just read about it. In short: The Human Variome Project (HVP) is the global initiative to collect and curate all human genetic variation affecting human health. Its mission is to improve health outcomes by facilitating the unification of data on human genetic variation and its impact on human health.

Key takeaways

Human Variome Project belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Human Variome Project to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Human Variome Project from memory before moving on to harder problems.

Reference excerpt

The Human Variome Project (HVP) is the global initiative to collect and curate all human genetic variation affecting human health. Its mission is to improve health outcomes by facilitating the unification of data on human genetic variation and its impact on human health.

Inception The HVP concept was conceived by Richard Cotton, a leader in the field of human genetic variation. His group, the Genomic Disorders Research Centre, based at the University of Melbourne and St. Vincent's Hospital, has established a consortium that covers genomic variation and its health implications in a comprehensive form. This consortium has encouraged the creation and supported many of the 571 gene specific variation databases currently available on the internet. However, these databases are of varying completeness and individualistic, so the Human Variome Project was born to establish a central project to encourage the collection and sourcing of this data, verifying it and ultimately using it for improved health outcomes. Geneticists, diagnosticians, researchers and bioinformatics scientists came together in June 2006 at the Human Variome Project Meeting, organized by Cotton’s team, and agreed to take on the task of organising data collection and unifying the systems of data access and storage. This initiative builds on substantial pilot work and achievements of the Human Genome Variation Society. The authority of those initiating this project is evidenced by the fact that major international bodies were present. These included WHO, OECD, European Commission, UNESCO, March of Dimes (US), Centers for Disease Control and Prevention (US), Google, representatives of two dozen international genetics bodies, numerous genetics journals, 20 countries and Australian State and Federal Governments. This major international project, a natural partner to the Human Genome Project, will require substantial funding to get it to a sustainable position. A five-year secure budget period of approximately US$12m per year has been proposed to initiate the project. This will enable the project to be organized and find operational funds for the tasks of system development, informatics, database curation and clinical access as well as collection systems that are open and accessible to all. The Human Variome Project seeks to provide open access to the full realm of genetic variation for the benefit of everyone. The Centre for Arab Genomic Studies (CAGS) has initiated efforts to proceed with the Arab Human Variome Project under the Human Variome Project. CAGS was one of the participants of the HVP meeting in Melbourne. Since then, several meetings have been held between officials of HVP and CAGS members to discuss the nature of work involved.

See also Variome Human Genome Project Human genetic variation Population groups in biomedicine

References

External links Official Project website

Worked examples

Example 1 — a first encounter with Human Variome Project

Start with the simplest possible case. Write down what Human Variome Project claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Human Variome Project before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Human Variome Project ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Human Variome Project

In research: Human Variome Project appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Human Variome Project in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Human Variome Project is common in secondary-school and first-year university syllabi. It links to neighbouring topics Human genome projects, Population genetics organizations, so understanding it makes those chapters shorter.
In everyday life: Look for Human Variome Project outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Human Variome Project in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Human Variome Project means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Human Variome Project out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Human Variome Project in simple terms?

Why does Human Variome Project matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Human Variome Project?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Human Variome Project.