Hydroxyanthraquinone glucosyltransferase (EC 2.4.1.181) is an enzyme that catalyzes the general chemical reaction
UDP-glucose + a hydroxyanthraquinone ⇌ {\displaystyle \rightleftharpoons } UDP + a glucosyloxyanthraquinone The two substrates of this enzyme characterised from Cinchona succiruba are a hydroxyanthraquinone and UDP-glucose. Its products are the corresponding glucosylated anthraquinone and uridine diphosphate (UDP). For example, emodin, an active component of several plants used in traditional Chinese medicine, is converted to emodin-8-glucoside:
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:hydroxyanthraquinone O-glucosyltransferase. Other names in common use include uridine diphosphoglucose-anthraquinone glucosyltransferase, and anthraquinone-specific glucosyltransferase.
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